Interpreting Genomic Variation: Inherited Cancer Susceptibility

St George's, University of London

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Start Date: 15 Apr, 2024
2 weeks
Study Content: Videos

Explore how robust variant interpretation is needed to support patients with increased risk of cancer.

Course Fee: Free

Certificate Cost: See Fees and Eligibility

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Course Description

This course is made available through the eLearnAfrica and FutureLearn partnership.

Explore germline variation in cancer susceptibility genes

Germline genomic variation can increase the risk of developing cancer. It’s essential to use the best evidence available to decide if a genomic variant is likely to increase the chance of a person developing cancer. This allows us to offer at-risk individuals access to appropriate screening, prevention, and personalised treatments.

Learn how to interpret genes for susceptibility to cancer

On this course, you will consider how variant interpretation in cancer susceptibility genes has different considerations when compared with variant interpretation in rare paediatric disease.

You’ll explore the guidelines produced by the UK Cancer Variant Interpretation Group (CanVIG-UK) for variant interpretation and how these can be applied to the American College of Medical Genetics (ACMG) framework in the classification of germline variants in cancer susceptibility genes.

Study the CanVIG-UK guidelines in theory and practice

This course will provide you with patient examples to explore the complexities of variant interpretation in cancer genomics. You’ll also hear from experts in the field about how the CanVIG-UK guidance was created.

You’ll be encouraged to apply your learning through case-based exercises that illustrate both the strengths and weaknesses of the tools and guidelines available for cancer variant interpretation.

Study with world-leading genomic experts at St George’s

Learn from Professor Kate Tatton-Brown and Dr Katie Snape – renowned consultant Clinical Geneticists leading on variant interpretation for rare disease and cancer.

This course is part of a series with Interpreting Genomic Variation: Fundamental Principles.

This course would be suitable for:

• Clinical Genetics doctors (consultant and specialist registrars)
• Clinical Scientists
• Genetic Counsellors
• Clinical Oncology doctors (consultants and specialist registrars)
• Pathologists undertaking cancer MDTs
• Specialist oncology nurses undertaking genetic testing

Certificate cost may vary. You will be redirected to the host page for cost and payment options.

St George's, University of London

St George’s is the UK’s only university dedicated to medical and health sciences education, training and research.

The university provides a world-class multi-professional health sciences education that equips graduates to meet today’s healthcare needs through relevant scientific research, clinical excellence, strong interpersonal skills and team-based working. Sharing a clinical environment with a major London teaching hospital, its innovative approach to education results in well-rounded, highly skilled clinicians, scientists, and health and social care professionals.

St George’s has more than 250 years of excellence and innovation in research and education resulting in groundbreaking advances in medicine and healthcare. Alumni include Edward Jenner, John Hunter, Muriel Powell and Patrick Steptoe. The university has three research institutes focus on biomedical and scientific discovery, advancing the prevention and treatment of disease in the fields of population health, heart disease and infection - three of the greatest challenges to global health in the 21st century.

This institution is available on eLearnAfrica through partnership with FutureLearn.

You may be able to download course materials after enrolling in this course. If not, all of the necessary course materials provided by the course instructor will be available on the provider's course page.

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